أكره أن أقول هذا أخي الكريم ولكن كلام الأطباء ليس كله صحيحاً بالضرورة ، إن كنت تجيد الإنجليزية فأنصحك أن تقرأ في هذه الصفحة عن الريميرون الجزء الخاص :
Low Dose vs. High Dose
https://www.psychdb.com/meds/antidep...e-vs-high-dose
وسأقتبسها لك هنا :
Why Do Lower Doses of Mirtazapine Cause More Sedation?
Mirtazapine acts mainly on 3 receptors: histaminergic, noradrenergic, and serotonergic receptors. However, at low doses (e.g. - 7.5 mg), mirtazapine has a higher affinity to (and thus preferentially blocks) the histamine-1 receptor, compared to the other 2 receptors.[2][3] At higher doses, this antihistamine activity is offset by increased noradrenergic transmission, which reduces its sedating effects.[4][5] Although sedation is expected at low doses, it is usually most noticeable in the first few weeks of therapy and diminishes with continued treatment