Antipsychotic and SNRI (serotonin-norepinephrine reuptake inhibitor) medications are known for affecting body temperature regulation and heat sensitivity, especially when the dose is on the higher side; however, this is a side effect that is not often discussed with individuals when being prescribed. I only found out about this side effect during my own research recently, and I discovered that a high body temperature during hot weather can lead to a very serious condition. Antipsychotic and SNRI medications affect the way the body is able to regulate its temperature, which can become a health hazard in hot and humid weather. Individuals on these medications do have the possibility of developing hyperthermia (a dangerously high rise in body temperature) when exposed to excessive heat. Temperatures that may feel comfortable for others may be increasingly uncomfortable for those on any of these medications, and extended self-care is a must.